Combined formulation developed for the fluid-particle mixture is introduced to simulate the biocube-fluid mixture flow, which is utilized for sewage disposal. Some tricky boundary conditions are introduced in order to simulate the effect of screen wall and air bubble, which is injected from the bottom of sewage reservoir. It has been shown that a circulated flow pattern, which was observed in experiment, is reproduced from the present numerical simulation. Furthermore, the effect of biocube density on the distribution pattern of biocube is also studied. It has been shown that a biocube whose density is slightly smaller than that of surrounding fluid or neutrally buoyant one are optimal for the uniform distribution of biocube.