This study explored the effects of emotional intelligence and sense of humor in institutionalized and at-home children on their aggressive behavior by using a path model. The participants in this study were 62 institutionalized children and 98 children reared at home, residing in an undisclosed city. The institutionalized children had a lower level of emotional intelligence and sense of humor than children at home. Also, the institutionalized children had a higher level of aggressive behavior than at-home children. Effects of emotional intelligence and sense of humor on the aggressive behavior were significantly different between institutionalized and at-home children.