During the irradiation tests of material and fuel rod, all components of the cylindrical structure with multiple holes act like heat sources due to high gamma heat and fission heat. The objective of this study is to formulate the general solution for the temperature distribution to estimate the thermal integrity of structure during irradiation tests. For the temperature distribution analysis, the two-dimensional heat conduction theory is used. The unmerical analysis is performed by the commercial finite element analysis code, ANSYS 6.1. If the cylindrical structure with hole number would not exceed three holes, the analysis results and finite element results are good agreement together. For the structure with four holes, the discrepancy between FE results and analysis results of the structural temperature distribution is increased.