Finite element analyses have been performed for the purpose of obtaining the robust and reliable design of engine cylinder block. Fatigue under high cycle operating loads is a primary concern and is evaluated by a probabilistic method. The robust and reliable design by a probabilistic method can provide satisfactory design conditions for the performance of the system under the influence of noise factors. Therefore, the design by this method will be desensitized to the uncontrollable noise factors. The simple methodology evaluates the distortion of main bore is proposed for the purpose of maintaining a well-controlled clearance between the crankshaft and main bores. The proposed methodology has proven a capability of predicting the distortion of the main bore under assembly, thermal, and firing loads. The calculated results are correlated well with the experimental ones.