In most researches on the ride comfort analysis of passenger vehicles, the flexibility of the vehicle body has been not considered as an important factor, because the resonance frequencies of the vehicle body related to pitching, yawing and rolling motions are below 10Hz while the resonance frequencies of the vehicle body related to the flexibility are above 20Hz approximately. Nevertheless, the paper shows that the consideration of the local flexibility (or local stiffness) of the 4 corners on which shock absorbers are mounted influences the ride comfort. A simple beam model is devised to qualitatively examine the effect of the change of the local stiffness of the vehicle body on the ride comfort. Based on the results obtained from the analysis of the one-dimensional model, multi-body dynamic analysis considering the flexibility of the vehicle body is performed using ADAMS and MSC/NASTRAN. Natural frequencies and mode shapes computed by MSC/NASTRAN are used as input data for multi-body dynamic analysis in ADAMS. Through simulations using ADAMS, it has been found that the ride comfort can be improved by changing the local stiffness of the vehicle body and that the simulation results agree with experiment results.