An OHT(Over Head Transportation) vehicle is an example of the industrial monorail vehicle, and it is used in the automobile, semiconductor, LCD manufacturing industries. OHT vehicle is moved by main wheels and guide rollers. The major function of the main wheel is to support and drive the OHT vehicle. The roles of the guide roller is the inhibition of derailment and steering of the OHT vehicle. Since the required vehicle velocity becomes faster and the required load capacity is increased, the durability characteristics of the wheel and roller, which was made of urethane, need to be increased. So it is necessary to estimate the fatigue life cycle of the wheel and roller. In this study, OHT dynamic model was developed by using the multi body dynamic analysis program ADAMS. Wheel and roller are modeled by the 3-D surface contact module. Especially, motor cycle tire mechanics is used in the wheel contact model. The OHT dynamic model can analyze the dynamic characteristic of the OHT vehicle with various driving conditions. And the result was verified by a vehicle traveling test. As a result of this study, the developed model is expected to predict wheel dynamic load time history and makes a contribution to design of a new monorail vehicle.