We performed the experimental and the numerical study on the comparison of thermal comfort performance indices for cooling loads in the lecture room for 4 cases: Fan coil unit(FCU) or 4-way cassette air-conditioner is respectively operated with the ventilation system or without. We measured the velocity, the temperature distribution and predicted mean vote(PMV) value in the lecture room for 4 different air-conditioning methods. Effective draft temperature(EDT) and PMV were investigated to analyze the characteristics of two thermal comfort indices in the lecture room and to compare their values each other. From the results we knew that there is the similarity between PMV values and EDTs when the room is air-conditioned for cooling loads. It turned out that definition of the control temperature is very important when the EDT is calculated. Finally EDT should not be used to predict the accurate thermal comfort in case that the temperature and humidity are suddenly varied and the zone affected by the solar and inner wall radiation.