Euclidean Voronoi diagram of spheres in 3-dimensional space has not been explored as much as it deserves even though it has significant potential impacts on diverse applications in both science and engineering. In addition, studies on the data structure for its topology have not been reported yet. Presented in this, paper is the topological representation for Euclidean Voronoi diagram of spheres which is a typical non-manifold model. The proposed representation is a variation of radial edge data structure capable of dealing with the topological characteristics of Euclidean Voronoi diagram of spheres distinguished from those of a general non-manifold model and Euclidean Voronoi diagram of points. Various topological queries for the spatial reasoning on the representation are also presented as a sequence of adjacency relationships among topological entities. The time and storage complexities of the proposed representation are analyzed.