Musculoskeletal Disorders(MSDs) have been a growing problems with higher incidence rate every year. The 65% of all work-related diseases in the US has been MSDs since the middle of the 90s according to BLS(Bureau of Labor Statistics, 1995). The MSDs in Korea has been increased in recent 10 years as well. This study has tried to focus on job stress associated with MSDs that has not been usually studied before. Specifically job stress of workers at automobile manufacturing industry and relationship between job stress and symptoms of MSDs have been major concerns in this study. The workers had higher stress with longer working experience, longer working hours, and worse working environment. The job stress had strong association with the symptoms at hand, wrist and low back. Specifically, job stress factors such as job requirement and job future ambiguity had more effects on the symptoms of MSDs.