This study was designed to evaluate the effects of oriental medicine therapy on insomnia and diabetic pruritus. This clinical case was analysed on a patient with diabetus mellitus whose main symptom was sleep disorder, which was attributed to pruritus. The patient was admitted on July 16th, 2004, and departed on September 3rd, 2004. He was treated internally and externally with herbal medicine, acupuncture, and bloodletting therapy. After treatment, pruritus and sleep disorder decreased. The study suggests that orental medicime therapy is effective in treatment of diabetic pruritus accompanied by insomnia.