Background and purpose: We evaluated the reliability of two electrodermal measurement devices on meridian skin areas; Electro Acupuncture according to Dr. Voll (EAV) method and newly developed MIR-1. Methods: Eighteen volunteers were tested repeatedly on the same condition with each device. To explore the intra-rater, inter-rater, and test-retest reliabilities, one rater tested each subject twice in succession, then the other rater tested the subject in a row. Finally, retests on the subjects with each device were performed 1 week later. The reliability was determined by Pearson correlation and intraclass correlation statistics. Results: EAV method showed poor reliability, while MIR-1 showed good reliability. Conclusion: It is suggested that further research on the reliability and useful device in both fields of clinical practice and biomedical research.