Experimental drug was applied to a white male mouse taken ill with allergic contact dermatitis to investigate the effects of Yanghyulsamultanggamibang. 1. In case of skin moisture, when it was checked 72 hours later, there showed up meaningful differences among the normal, control, and sample groups. Especially, the moisture increased more noticeably in the sample group than in the control group. 2. With regards to RBC count in blood, it increased more in the control and sample groups than in the normal group when it was checked both in 24 hours and 72 hours. When it was checked in 48 hours, the number of RBC in the sample group increased the most, and the count in the control group increased more than in the normal group. 3. About the neutrophil rate in WBC count, it increased meaningfully more both on the control and sample groups than in the normal group in 24 hours. When the rate was checked in 48 hours, it increased the most in the sample group, and it increased more in the control group than in the normal group. When in checked72 hours later, it increased substantially more in the control group than both the sample and normal group. 4. As of the lymphocyte rate in WBC count, when measured in 24 hours, it increased in the normal group than in the control and sample groups. In 48 hours, it increased the most in the normal group, and it increased meaningfully more in the control group than in the sample group. 5. Regarding the total IgE, when measured 24 hours later, it increased noticeably more in the normal group than in the control and sample groups. In 48 hours, there showed up substantial differences among the normal, control and sample groups. In particular, it increased meaningfully more in the control group than in the sample group. 6. When the sample of skin tissue was examined, the corneal layer restoration increased more in the sample group than in the normal group. The above-mentioned results prove that Yanghyulsamultanggamibang can be taken when allergic contact dermatitis develops on the skin. Long-term observation afterward is also advised.