Recently plastic parts are molded for the purpose of mass production in multi-cavity system. Therefore, designer is usually designing mold that has geometrically balanced runner lay-out for filling balance at each cavity. Although, mold is manufactured with geometrically balanced runner lay-out, there are actually filling imbalances in the cavities. These filling imbalances phenomenon are caused by complicated interaction between melt and mold. In this study, based on previous studies for filling imbalances in cold-runner mold, filling imbalances in hot-runner mold were investigated by CAE and injection molding experiments. ABS and PMMA as amorphous polymer, PA as crystalline polymer were used to compare the filling imbalances. There were different results of CAE and experiment. The filling imbalances decreased as injection rate increased without regard to kind of resins and were lower than the one of cold-runner.