Odontogenic myxoma is a benign neoplasm composed of a uniform myxoid appearance that is believed to arise from the primitive mesenchymal portion of the tooth germ. It appears as painless swelling, but it should be distinguished from cystic lesion or other benign tumor. Although odontogenic myxoma is benign, its behavior is known to be aggressive and infiltrative, so thorough curettage and enucleation is necessary. We report a case of odontogenic myxoma of the mandible observed in our clinic with good prognosis after enucleation was done.