The subchannel analysis capability of MARS, a multi-dimensional thermal-hydraulic system code, has been enhanced. In particular, the turbulent mixing and void drift models for the flow-mixing phenomena in rod bundles were improved. Then, the subchannel analysis feature was combined with the existing coupled system thermal-hydraulics (T/H) and 3D reactor kinetics calculation capability of MARS. These features allow for more realistic simulations of both the hot channel behavior and the global system T/H behavior. Using the coupled features of MARS, a coupled analysis of a main steam line break (MSLB) is carried out for demonstration purposes. The results of the calculations are very reasonable and promising.