Recently, the issue of ship nitration due to the large scale, high speed and lightweight of ship is emerging. For pleasantness in the cabin, shipbuilders are asked for strict vibration criteria and the degree of nitration level at a deckhouse became an important condition for taking order from customers. This study proposes a new optimization framework that is NASTRAN external call type optimization method (OptShip) and applies to an optimum design to decrease the nitration level of a deckhouse. The merits of this method are capable of using of global searching method and selecting of various objective function and design variables. The global optimization algorithms used here are random tabu search method which has fast converging speed and searches various size domains and genetic algorithm which searches multi-point solutions and has a good search capability in a complex space. By adapting OptShip to full-scale model, the validity of the suggested method was investigated.