Database security is essential to protect their data in most organization such as hospitals, central or local governments, banks which manage the private, sensitive and important data. Because the duty of the department recently became more various and complicated, the changes of security requirement are needed more frequently. Therefore, easily changeable, flexible security policy and efficient security management with preserving the integrity of security policy are very important. In this paper, we implemented a flexible database security system in the specimen and clinical information management system of leukemic research center using IRH(Improved Role Hierarchy). Data is protected by MAC and we propose a flexible access control and effective administration by using the IRH that is an improved role hierarchy of RBAC. If security policy is needed for changes, this system can do it easily by simply modifying the IRH with the decentralized administration. The modified security policy can be applied flexibly after alteration because the security level of the subject is not fixed but can be derived automatically from the IRH when user connects the system.