This paper presents an ASF (Aluminum Space Frame) BIW (Body in White) optimal design, which minimizes weight and satisfies multidisciplinary constraints such as static stiffness, vibration characteristics, low-/high-speed crash, and occupant safety. As only one cycle CPU time for all the analyses is 12 hours, the ASF design having 11-design variable is a large scaled problem. In this study, ISCD-II and conservative least square fitting method were used for efficient RSM modeling. Likewise, the ALM method was used to solve the approximate optimization problem. The approximate optimum was sequentially added to remodel the RSM. The proposed optimization method uses only 20 analyses to solve the 11-design variable problem. Moreover, the optimal design can achieve $15.6\%$ weight reduction while satisfying all the multidisciplinary design constraints.