Objectives : This study was performed to examine the anti-allergic and anti-inflammatory effects of Jacho (Lithospermum erythrorhizon). Methods : Macrophage 264.7 cells were pretreatment, macrophage were incubated with lipopolysaccharide(LPS) 100ng/ml for 12h ($TNF-{alpha}$, IL-6) or 24h ($IL-1eta$, IL-10) and media collectred and $TNF-{alpha}$, IL-6, $IL-1{eta}$, and IL-10 concentrations in supernatants were each measured by enzyme-linked immunosorbent assay. Concentrations of Jacho used were 50, 100, 250, 500, and $1000{mu}g/ml$, and hydrocortisones used were 10-8, 10-7, 10-6, 10-5, and 10-4M. Results : Jacho showed inhibitory effect on $TNF-{alpha}$ LPS-stimulated macrophage 264.7. The inhibitory effect was most significant in $250{mu}g/ml$, and was not in a dose-dependent manner as in the hydrocortisone group Jacho also showed inhibitory effect on IL-6 by LPS-stimulated macrophage 264.7. The inhibitory effect was most significant in $1000{mu}g/mL$, and increased in a roughly dose-dependent manner. Jacho and hydrocortisone showed contrary effect on $IL-1eta$. Jacho obviously increased the expression of $IL-1eta$, in alt five concentrations, End at the fewest concentration $(50{mu}g/ml)$ the level of $IL-1eta$, was highest. On the other hand, hydrocortisone was observed to have inhibitory effect on $IL-1eta$, in all five concentrations. IL-10 was obviously inhibited by Jacho and hydrocortisone respectively in a roughly dose-dependent manner. Conclusions : By the findings of this experiment. Jacho was observed to have anti-allergic and anti-inflammatory effects through inhibiting pro-inflammatory cytokine $TNF-{alpha}$ and IL-6, and might be one of the effective therapeutic regimens for allergic diseases.