In this report for the assessment of creep properties of high-temperature tube materials in power plants, the long-time($10^4$~105h) creep life prediction by ISM for 2.25Cr1Mo steel was studied. It was clarified experimentally and quantitatively that the newly developed long-time creep life prediction equation was very coincident with the actual experimental data with high confidence, and the model was $t_r=alphavarepsilon_0^{eta}sigma^{-1}$.