The purpose of this research is to develop the model of pressure drop per unit pipe length due to the turbulence modulations in particle-laden flows which can be applied to various fluid conditions. The wake behind a particle, particle size, loading ratio and density difference between two phases of particle-laden flow was considered. The frictional pressure drop was modeled with the force balance in control volume. The numerical results show good agreements with available experimental data and the model success-fully predicted the mechanism of the pressure drop in particle-laden flows.