The growing emphasis on knowledge management is given to research institutes whose work processes including R&D are mainly focused on knowledge or technology. It is due to the fact that the system integrating, sharing and generating knowledge serves as the growth engine of those institutes. This study creates the knowledge management framework based on the research process which is the key process in research institutes, and applies to POSCO Research Institute(POSRI) who is a leading institute in this domain. Practical framework and methodology are found in POSRI through systematic operation of knowledge management process.