Fretting is the oscillatory motion with very small amplitudes, which usually occurs between two solid surfaces in contact. Fretting wear is the removal of material from contacting surfaces through fretting action. Fretting wear of steam generator tubes in nuclear power plant becomes a serious problem in recent years. The materials for the tubes usually are Inconel 690 (I-690) and Inconel 600 (I-600). In this paper, fretting wear tests for I-690 and I-600 were performed under various applied loads in water at room temperature. Results showed that the fretting wear loss of I-690 and I-600 tubes was largely influenced by stick-slip. The fretting wear mechanisms were the abrasive wear in slip regime and the delamination wear in stick regime. Also, I-690 had somewhat better wear resistance than I-600.