The genetic algorithm (GA) which is one of the popular optimum algorithm has been used to solve a variety of optimum problems. Because it need not require the gradient of objective function and is easier to find global solution than gradient-based optimum algorithm using the gradient of objective function. However optimum method using the GA and the finite element method (FEM) takes many computational time to solve the optimum structural design problem which has a great number of design variables, constraints, and system with many degrees of freedom. In order to overcome the drawback of the optimum structural design using the GA and the FEM, the author developed a computer program which can optimize frame structures by using the GA and the generalized transfer stiffness coefficient method. In order to confirm the effectiveness of the developed program, it is applied to optimum design of plane frame structures. The computational results by the developed program were compared with those of iterative design.