Base isolation technologies have been proven to be very efficient in protecting structures from seismic hazards during experimental and theoretical studies. In recent years, there have been more and more engineering applications using base isolators to upgrade the seismic resistibility of structures. Optimum design of the base isolator can lessen the undesirable seismic hazard with the most efficiency. Hence, tracing the nonlinear behavior of the base isolator with good accuracy is important in the engineering profession. In order to predict the nonlinear behavior of base isolated structures precisely, hundreds even thousands of degrees-of-freedom and iterative algorithm are required for nonlinear time history analysis. In view of this, a simple and feasible exact formulation without any iteration has been proposed in this study to calculate the seismic responses of structures with base isolators. Comparison between the experimental results from shaking table tests conducted at National Center for Research on Earthquake Engineering in Taiwan and the analytical results show that the proposed method can accurately simulate the seismic behavior of base isolated structures with elastomeric bearings. Furthermore, it is also shown that the proposed method can predict the nonlinear behavior of the VCFPS isolated structure with accuracy as compared to that from the nonlinear finite element program. Therefore, the proposed concept can be used as a simple and practical tool for engineering professions for designing the elastomeric bearing as well as sliding bearing.