In this study two single-bay, three-storey space frames, one with brick masonry infill in the second and third floors representing a soft-storey frame and the other without infill were designed and their 1:3 scale models were constructed according to non-seismic detailing and the similitude law. The models were excited with an intensity of earthquake motion as specified in the form of response spectrum in Indian seismic code IS 1893-2002 using a shake table. The seismic responses of the soft-storey frame such as fundamental frequency, mode shape, base shear and stiffness were compared with that of the bare frame. It was observed that the presence of open ground floor in the soft-storey infilled frame reduced the natural frequency by 30%. The shear demand in the soft-storey frame was found to be more than two and a half times greater than that in the bare frame. From the mode shape it was found that, the bare frame vibrated in the flexure mode whereas the soft-storey frame vibrated in the shear mode. The frames were tested to failure and the damaged soft-storey frame was retrofitted with concrete jacketing and, subjected to same earthquake motions as the original frames. Pushover analysis was carried out using the software package SAP 2000 to validate the test results. The performance point was obtained for all the frames under study, therefore the frames were found to be adequate for gravity loads and moderate earthquakes. It was concluded that the global nonlinear seismic response of reinforced concrete frames with masonry infill can be adequately simulated using static nonlinear pushover analysis.