This paper describes the area of intelligent systems research as funded by the Civil and Mechanical Systems (CMS) Division of the National Science Foundation (NSF). With developments in computer science, information technology, sensing and control the design of typical machines and structures by civil and mechanical engineers is evolving toward intelligent systems that can sense, decide and act. This trend toward electro-mechanical design is well-established in modern machines (e.g. vehicles, robots, disk drives) and often referred to as mechatronics. More recently intelligent systems design is becoming an important aspect of structures, such as buildings and bridges. We briefly review recent developments in structural control, including the role that NSF has played in their development, and discuss on-going CMS activities in this area. In particular, we highlight the interdisciplinary initiative on Sensors and Sensor Networks and the Network for Earthquake Engineering Simulation (NEES). NEES is a distributed cyberinfrastructure to support earthquake engineering research, and provides the pioneering NEES grid computing environment for simulation, teleoperation, data collection and archiving, etc.