The purpose of this research is to suggest the roles of government through constructing models of regional scientific technology and information to develop regional innovation system, which can maximize international competitiveness of Korea. To do this, this research compares the characteristics and superiorities of each regional areas in Korea. Constructing DB for scientific technology and information is recognized as a primary factor for constructing scientific technology and information infrastructure. In regional areas, constructing DB for professional scientific technology and information and networks are regarded as a key factor for regional scientific technology and information. Also, the primary problem to be solved in the regional areas is to construct DB for scientific technology and information.