- 초음파가 닭의 관절연골에 미치는 영향
- ㆍ 저자명
- 최보경,이재형,박장성,Choi. Bo-Kyung,Lee. Jae-Hyoung,Park. Jang-Sung
- ㆍ 간행물명
- 대한임상전기생리학회지
- ㆍ 권/호정보
- 2005년|3권 1호|pp.13-29 (17 pages)
- ㆍ 발행정보
- 대한임상전기생리학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
This study was performed to examine the effects of therapeutic doses of ultrasound on cell migration distance and proliferation of biopsies from articular cartilage. Articular cartilage biopsies were isolated from proximal part of the tibial of chicken, and cultured. Cartilage explants were exposed for a single 5 min to ultrasound with $0.1{sim}1.6;W/cm^2$ (spatial average-temporal average) at a frequency of 1 MHz. A control group was treated with the ultrasound generator switched off. The cell migration distance and cell proliferation analysis were performed on day 6 after stimulation of ultrasound. The results revealed that ultrasound influenced cell migration distance and cell proliferation in intensity-dependent manner. It was found that ultrasounds at $0.2;W/cm^2$, $0.4;W/cm^2$, and $0.8;W/cm^2$ were significantly increase respectively both cell migration distance and cell proliferation (p<0.05). However, cell migration distance and cell proliferation were not affected by exposure ultrasound at $0.1;W/cm^2$ and $1.6;W/cm^2$ compared with control group. These results suggest that low-intensity ultrasounds at $0.2;W/cm^2$, $0.4;W/cm^2$, and $0.8;W/cm^2$ may stimulate cell proliferation of the chondroblasts, and reflect a potential role in cartilage repair.