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저자명
최보경,이재형,박장성,Choi. Bo-Kyung,Lee. Jae-Hyoung,Park. Jang-Sung
간행물명
대한임상전기생리학회지
권/호정보
2005년|3권 1호|pp.13-29 (17 pages)
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대한임상전기생리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

This study was performed to examine the effects of therapeutic doses of ultrasound on cell migration distance and proliferation of biopsies from articular cartilage. Articular cartilage biopsies were isolated from proximal part of the tibial of chicken, and cultured. Cartilage explants were exposed for a single 5 min to ultrasound with $0.1{sim}1.6;W/cm^2$ (spatial average-temporal average) at a frequency of 1 MHz. A control group was treated with the ultrasound generator switched off. The cell migration distance and cell proliferation analysis were performed on day 6 after stimulation of ultrasound. The results revealed that ultrasound influenced cell migration distance and cell proliferation in intensity-dependent manner. It was found that ultrasounds at $0.2;W/cm^2$, $0.4;W/cm^2$, and $0.8;W/cm^2$ were significantly increase respectively both cell migration distance and cell proliferation (p<0.05). However, cell migration distance and cell proliferation were not affected by exposure ultrasound at $0.1;W/cm^2$ and $1.6;W/cm^2$ compared with control group. These results suggest that low-intensity ultrasounds at $0.2;W/cm^2$, $0.4;W/cm^2$, and $0.8;W/cm^2$ may stimulate cell proliferation of the chondroblasts, and reflect a potential role in cartilage repair.