A mathematical model, GUNBLAST, of blast waves emitted from a gun muzzle is established, and structural response analyses for the blast load are performed. The blast wave can be divided into two kinds of waves, free field and reflected blast waves. In this research, the free field blast wave model is established by the use of a scaling approach, and the reflected blast wave is calculated by using the oblique shock theory and computational fluid dynamic calculation. GUNBLAST is applied to two kinds of structural models. To investigate the effect of the muzzle distance from a structural surface, the blast waves on a plate for various muzzle distances are compared to uniform loads. Moreover, the transient response analysis of an aircraft wing model with a 12.7mm gun is carried out by using MSC/NASTRAN. From the results, it can be shown that the blast wave can cause broad random vibration and high frequency damage to equipments mounted in the aircraft.