We, in this paper, suggest the Yeosu internationalization strategy for holding the 2012 World EXPO in Yeosu successfully, First of all, we analyze some problems that hinder the internationalization of Yeosu. Our analysis, also, provides several strategic solutions to those problems by foreign direct investment, international trade, hub port development, and international tourism. first strategy is to create a more favorable business environment for foreign investors. Foreign direct investment is the most effective way to internationalize the specific district. Second strategy is to expand the export of small and medium-sized firms in Yeosu. Especially, local firms with agricultural/fishery products have to develop various new products and introduce the effective international marketing strategy. Final strategy is to develop the hub port in Yeosu and the new tourist resources to attract foreign tourists.