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Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II
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  • Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II
  • Synthesis and Antibacterial Activity of 1β-Methyl-2-[5-(α,β-disubstituted ethyl)pyrrolidin-3-ylthio]carbapenem Derivatives. Part II
저자명
Kim. Jin-Woong,Park. Hyeong Beom,Chung. Bong Young,Lee. Jong Baek,Cho. Jung-Hyuck,Oh. Chang-Hyun
간행물명
Bulletin of the Korean Chemical Society
권/호정보
2006년|27권 8호|pp.1164-1170 (7 pages)
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대한화학회
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The synthesis of a new series of 1$eta$-methylcarbapenems having 5-($alpha,eta$-disubstituted ethyl)pyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound (VIh) having $alpha$-hydroxy-$eta$-piperazinylethyl substituted moiety showed the most potent activity.