This thesis is a study on the Significance of Pulse in Internal Classic(內經脈義) in the Chapters on Vitality of Pulse(脈神章) in the Complete Works of Zhang Jingyue(景岳全書) Vol. IV. The Complete Works of Zhang Jingyue(景岳全書) is composed of 64 volumes. Maishenzhang, the Chapters on Vitality of Pulse(脈神章) is composed of 3 chapters. The first chapter is the Significance of Pulse in Internal Classic(內經服義). The terminology, Maishen(脈神) means the Vitality of Pulse, which was introduced by Zhang Jingyue to emphasize that the keypoint of sphygmological diagnosis is the vitality of pulse. The Significance of Pulse in Internal Classic(內經脈義) is composed of 20 parts including Buwei(部位), Maidu(脈度), Sanbujiuhou(三部九候), Qizhen(七診), Liujingmaoti(六經脈體), ect. in Miraculous Pivot(靈樞). There are no commentaries in most of them, which is because there are explanatory notes in Leijing(類經). Therefore, I referred to explanatory notes in Leijing(類經) to study the Significance of Pulse in Internal Classic(內經脈義), and make a study as followings.