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Rubus coreanus Unripe Fruits Inhibits Immediate-type Allergic Reaction and Inflammatory Cytokine Secretion
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  • Rubus coreanus Unripe Fruits Inhibits Immediate-type Allergic Reaction and Inflammatory Cytokine Secretion
  • Rubus coreanus Unripe Fruits Inhibits Immediate-type Allergic Reaction and Inflammatory Cytokine Secretion
저자명
Shin. Tae-Yong,Shin. Hye-Young,Kim. Sang-Hyun,Kim. Dae-Keun,Chae. Byeong-Suk,Oh. Chan-Ho,Cho. Moon-Gu,Oh. Suk-Heung,Kim. Jong-Hw
간행물명
Natural product sciences
권/호정보
2006년|12권 3호|pp.144-149 (6 pages)
발행정보
한국생약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The immediate-type allergic reaction (anaphylaxis) is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic diseases is a very important subject in human health. In this study, we investigated the effect of Rubus coreanus Miq.(Rosaceae) unripe fruits (RCF) on mast cell-mediated allergic reaction and inflammatory cytokine secretion. RCF inhibited compound 48/80-induced systemic reactions in mice. RCF attenuated immunoglobulin (Ig) E-mediated local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells local allergic reactions. In addition, RCF dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. Furthermore, RCF decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor $(TNF)-{alpha}$ and interleukin (IL)-6 secretion in human mast cells. Our findings provide evidence that RCF inhibits mast cell-derived immediate-type allergic reactions.