This study was worked out to investigate antioxidant activity of solvent extracts from wild grape skin by measuring electron donating ability (EDA), reducing power, superoxide dismutase (SOD)-like activity, thiobarbituric acid reactive substances (TBARS) and nitrite scavenging ability. Total phenolic compound and flavonoids contents were the highest in ethyl acetate extract, $54.4{pm}1.18;mg/100;g$ and $645.1{pm}5.05;mg/100;g$, respectively. The EDA and reducing power of solvent extracts from wild grape skin were proportionally increased with concentration and ethyl acetate extract $(79.2{pm}0.06%)$ showed the stronger than BHT $(74.1{pm}0.15%)$ at concentration of $100;{mu}g/mL$, especially. SOD-like ability of ethyl acetate $(25.1{pm}0.41%)$ and butanol $(20.2{pm}0.13%)$ extracts were stronger than other extracts at concentration of $100;{mu}g/mL$. TBARS of ethyl acetate extract was higher than ascorbic acid. Nitrite scavenging ability of solvent extracts from wild grape skin (pH 2.5, $1000;{mu}g/mL$) were in order of ethyl acetate $(90.5{pm}0.75%)$>butanol $(65.9{pm}2.16%)$>hexane $(58.1{pm}1.74%)$>chloroform $(55.4{pm}1.02%)$>water $(40.9{pm}0.35%)$. Antioxidant activity of solvent extracts from wild grape skin was the highest in ethyl acetate extract from the results of our experiments.