In this study, advanced computational analysis system has been developed in order to investigate flow-induced vibration(FIV) phenomenon for general stator-rotor cascade configurations. Relative movement of the rotor with respect to stator is reflected by modeling Independent two computational domains. Fluid domains are modeled using the unstructured grid system with dynamic moving and local deforming methods. Unsteady, Reynolds-averaged Wavier-stokes equations with one equation Spalart-Allmaras and two-equation SST ${kappa}-{varepsilon}$ turbulence models are solved for unsteady flow problems and also relative moving and vibration effects of the rotor cascade are fully considered. A coupled implicit time marching scheme based on the Newmark integration method is used for computing the governing equations of fluid-structure interaction problems. Detailed vibration responses for different flow conditions are presented and then vibration characteristics are physically investigated in the time domain as computational virtual tests.