The problem of an infinite anisotropic material with a crack inclined with respect to the principal material axes is analyzed. The material is subjected to uniform biaxial load along its boundary. It is assumed that the material is homogeneous, but anisotropic. By considering the effect of the horizontal load, the distribution of stresses at the crack tip is analyzed. The problem of predicting critical stress in anisotropic solids which is a subject of considerable practical importance is examined and the effect of load biaxiality is made explicitly. The present results based on the normal stress ratio theory show significant effects of biaxial load, crack inclination angle and fiber orientation on the critical stress. The analysis is performed for a wide range of the crack angles and biaxial loads.