An experimental investigation was performed to study flow boiling heat transfer of deionized water in a microchannel. Measurement and evaluation of boiling heat transfer coefficients were carried out using a single horizontal rectangular microchannel having a hydraulic diameter of $100{mu}m$. Tests were performed for mass fluxes of 90, 169 and 267 $kg/m^2$s and heat fluxes of 200-700 $kW/m^2$. Test results showed that the measured boiling heat transfer coefficients had no dependence on mass flux and vapor quality. Most macro-channel correlations of boiling heat transfer coefficient did not provide reliable predictions.