This study was aimed to analyze the influences of urban expansion by developing a new large scale residential district on changes of whole urban spatial structure. For the analysis, time serial analysis was conducted on the Daejeon Metropolitan City by using the space syntax method. The results of the study are as follows ; First, an expansion of urban area led to lower both of the local and global integration levels, second, the spatial occupation ratio of upper 10% in the whole integration showed that old city center was separated, and moved to the Dunsan District, third, the results also showed that an integration of the old city center region maintained a high level in spite of a movement of city center and its local integration still had highest level so that the old city center will take one of the two city center roles together with Dunsan District.