This paper is intended to trace and management of drug based on RFID Technology at a circulation market, from manufacturer to end user, of drug. To avoid counterfeit and generic drug and establish of order in the circulation of drug, at the moment of manufacturing, tags for each bottle and each box are tagged. and then from factory to hospital, through whole logistics, e-pedigree for the drug is made and monitored. Using inventory information, it is easy to manage and control stock of drug. In addition to, RFID System enables storing and delivery to be simple, process time to be shortened. As this research is to study of applying RFID to drug, in this paper, standard RFID code for drug is suggested and tried to apply domestic middle win. Finally, the result of tag pattern design and how to tag for the drug based on 90Mhz is proposed.