This study was carried out to investigate the relationship of the cadmium and lead levels in blood by age, gender and smoking status among 181 students in Gyeongnam province from June 2005 to July 2006. The cadmium and lead levels in blood was analyzed by atomic absorption spectrophotometer. Subjects were classified for the investigation according to smoking status as smokers and nonsmokers, age and gender. Mean blood cadmium level in male and female was $1.65{mu}g/dl,;1.10{mu}g/dl$ respectively. Male was significantly higher than that of female. Blood cadmium levels in heavy smokers ($11{sim}20;ea/day$) and light smokers ($1{sim}10;ea/day$) were $2.34{mu}g/dl,;1.10{mu}g/dl$ respectively. Heavy smokers were significantly higher than those of light smokers. In the comparison of age, gender and smoking status in blood Lead levels were no significant differences. In conclusion, heavy smoking was the most significant risk factor to increase blood cadmium levels. The further study will need analysis of the other factors related to the elevation of the cadmium and lead levels.