In this research, in order to study the spray, combustion, and emission characteristics of the common rail DME engine, the target engine was disassembled, and 3D CAD file was constructed using a 3D measurement machine and a rapid prototyping machine. Using the obtained 3D geometry, fine moving meshes are generated, and three dimensional non-steady turbulence flow field and combustion phenomenon including spray were numerically analyzed. As a result, IMEP of DME and diesel in medium and high speed revolution showed similar performance. As the DME fuel start to burn in spray area, the vaporized fuel rapidly spreads squish area in low speed revolution. In the case of DME engine, CO and NOx are relatively consistent with experiment results. It was found that the break-up, evaporation, collision model of DME fuel need to be properly adjusted through matching the characteristics of fuel and injector for further improvement.