The experimental and the numerical study was performed on the comparison of thermal comfort(TC) and indoor air quality(IAQ) in the lecture room for cooling loads when the operating conditions are changed. PMV value and $CO_2$ concentration of the lecture room were measured and compared with the numerical results. The numerical results showed a good agreement with the experimental one and then the numerical tool was used to analyze thermal comfort and IAQ for a couple of operating conditions. As a result it was found that the increment of the discharge angle of system air-conditioner makes TC uniformity worse, but rarely affects IAQ. Also TC and IAQ were hardly affected by the variation of the discharge airflow. Finally it turned out that TC is merely affected by the increment of the ventilation airflow, but the average $CO_2$ concentration can be satisfied with Japanese IAQ standards of classrooms when the ventilation airflow is more than $800m^3/h$ in this study.