The quantification analysis problem is that how the m entities that have n characteristics can be linked to p-dimension space to reflect the similarity of each entity In this paper, the optimization approach for the quantification analysis problem using neural networks is suggested, and the performance is analyzed The computation of average variation volume by mean field theory that is analytical approximated mobility of a molecule system and the annealed mean field neural network approach are applied in this paper for solving the quantification analysis problem. As a result, the suggested approach by a mean field annealing neural network can obtain more optimal solution than the eigen value analysis approach in processing costs.