In order to consider the effect of Karman vortex for mixing, mixing indices are calculated for 4 models of micro channel flows driven from the combinations of a circular cylinder and a oscillating stirrer. And their results are compared to that of a simple straight micro channel flow(model I). The mixing rate is improved 5.5 times by Karman vortex (model II) and 11.0 times by the stirrer(model III) respectively. In case of successive mixing by the cylinder and the stirrer(model IV), $27\%$ of shortening the channel length for the complete mixing as well as 1.37 times improvement of mixing efficiency then model III. And then, variation of mixing indices are much stable comparing with the others. Thus, it is found that the Karman vortex plays a good role as a pre-mixing method. The D2Q9 Lattice Boltzmann methods are used.