Using a deterministic design optimization, the effect of uncertainty can result in violation of constraints and deterioration of performances. For this reason, design optimization is required to guarantee reliability for constraints and ensure robustness for an objective function under uncertainty. Therefore, this study drew Monte Carlo Simulation(MCS) for the evaluation of reliability and robustness, and selected an artificial neural network as an approximate model that is suitable for MCS. Applying to the aero-structural optimization problem of aircraft wing, we can explore robuster optima satisfying the sigma level of reliability than the baseline.