The purpose of this study is to investigate the relationships between the biological base of coping strategy and the different constitutions. First of all, subjects were divided in to 3 groups dy Questionnaire for the Sasang Constitution Classification II and Yin-Yang Property Analysis. Then each group was assigned into two experimental coping conditions, active and passive condition, in turn. The SDNN(The Standard Deviation of the NN Intervals) of HRV(Heart rate variability) index was estimated from two conditions after giving a aversive pain stimulus. The results of the study were as follows 1. The interaction between constitution and coping condition is significant(p<0.05). 2. The SDNNs of Shaoyangren are higher than those of Taiyinren under passive condition but it was opposite under active condition(p<0.05). 3. The main effect of constitution is also significant but that of coping condition is not significant. 4. Thee Shaoyangren is higher than Shaoyinren in multiple comparisons(p<0.05). 5. The interaction between Yin-Yang constitution and coping condition is significant and the main effect of only constitution is significant(p<0.05). According to these results, different constitution can respond differently to coping condition and It is highly related to biological mechanism associated with two basic coping strategies.