Linkage Disequilibrium (LD) Mapping and Tagging SNP Selection of C-Fos Induced Growth Factor (Figf) Gene in Korean Population

Linkage Disequilibrium (LD) Mapping and Tagging SNP Selection of C-Fos Induced Growth Factor (Figf) Gene in Korean Population
Linkage Disequilibrium (LD) Mapping and Tagging SNP Selection of C-Fos Induced Growth Factor (Figf) Gene in Korean Population

ㆍ 저자명: Kim. Sook,Yoo. Yeon-Kyung,Jang. Hye-Yoon,Shin. Eun-Soon,Cho. Eun-Young,Kim. Eu-Gene,NamKung. Jung-Hyun,Yang. Jun-Mo,Lee. Jong-Eu
ㆍ 간행물명: Molecular & cellular toxicology
ㆍ 권/호정보: 2006년|2권 1호|pp.7-10 (4 pages)
ㆍ 발행정보: 대한독성유전단백체학회
ㆍ 파일정보: 정기간행물|ENG|
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ㆍ 주제분야: 기타

이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.

서지반출

기타언어초록

We performed comprehensive SNP validation and linkage disequilibrium (LD) analysis of the c-fos induced growth factor (Figf) gene in Korean population. Out of 32 SNPs, only 9 SNPs were polymorphic in Korean population. Validated SNPs formed a single extended haplotype block with strong LD through the entire length of the gene. Tagging SNP analysis picked only 2 SNPs to represent most of the genetic variation information of the Figf gene. Our results demonstrate the utility of LD block and tagging SNP analysis for an efficient way of performing a candidate gene based association study.

키워드

SNP FigF gene Haplotype Linkage disequilibrium

다운URL