The efficiency of ventilation system is one of the most important issues of designing ventilation in high-rise apartment buildings. The purpose of this study is to analyze the ventilation efficiency of ventilation system by experimental study using CO2 gas method. The results of this paper can be summarized as follows; (1) An appropriate ventilation including opening planning, mechanical and hybrid system are required. (2) The supply diffuser of ventilation system should be located near the contaminant source. (3) The return grill should be located along with supply diffuser for proper ventilation. and the return grill should be located near or right above the contaminant source. (4) However, the supply location right above the contaminant source has to be avoided. and the supply diffuser should be installed in module with return grill increase ventilation effectiveness.