Performances of variable sampling interval(VSI) multivariate control charts with accumulate-combine approach for monitoring mean vector of p related quality variables were investigated. Shewhart control chart is also proposed to compare the performances of CUSUM and EWMA charts. Numerical comparisons show that performances of CUSUM and EWMA charts are more efficient than Shewhart chart for small or moderate shifts, and VSI chart is more efficient than fixed sampling interval(FSI) chart. We also found that performances of the CUSUM or EWMA chart with accumulate-combine approach are substantially efficient than those of Shewhart chart.